Methadone (Dolophine, Methadose) is an inexpensive drug used to treat severe pain. It is slightly more popular than comparable drugs. It is available in multiple generic and brand versions. Generic methadone is covered by most Medicare and insurance plans, but some pharmacy coupons and cash prices may be lower. The lowest GoodRx price for the most common version of methadone is around $10.26, 75% off the average retail price of $41.10. Compare opioids.